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pharmacodynamic antagonism. Steer clear of or Use Alternate Drug. Coadministration may result in a substantial lessen in renal operate. NSAIDs may diminish the antihypertensive result of ACE inhibitors. The mechanism of these interactions is likely relevant to the ability of NSAIDs to lessen the synthesis of vasodilating renal prostaglandins.
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Watch Closely (1)aspirin, xanomeline/trospium. Both will increase amounts of one other by decreasing elimination. Use Warning/Observe. Coadministration of trospium with other medicines removed by Lively tubular secretion may maximize plasma concentrations of trospium and/or perhaps the concomitantly used drug owing to Competitiveness for this elimination pathway. Keep an eye on for increased frequency and/or severity of adverse reactions.
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